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Riboflavin Tetrabutyrate

Catalog No. T16747 CAS 752-56-7

Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and Lipid peroxide-removing activity.

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Riboflavin Tetrabutyrate, CAS 752-56-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.
In vitro	Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. During the process of the enzymic oxidation-reduction reaction, Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids[1].
In vivo	Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver, and so on through the inhibition of lipid peroxide, thereby resulting in a decrease of the elevated serum lipid. The increase in hepatic 3-ketoacyl-CoA thiolase activity indicates that prolonged Riboflavin Tetrabutyrate administration induces an increased beta-oxidation of fatty acid in the liver. Feeding of Riboflavin Tetrabutyrate causes an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected [1][2].

Molecular Weight	656.72
Formula	C33H44N4O10
CAS No.	752-56-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (152.27 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8. 2. Okuno E, et al. Effect of chronic administration of riboflavin 2',3',4',5'-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42. 3. Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavin nucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9.

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Keywords

Riboflavin Tetrabutyrate 752-56-7 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibit Inhibitor inhibitor

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