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SF1670

Catalog No. T6667 CAS 345630-40-2

Synonyms: PTP CD45 Inhibitor, PTPase CD45 Inhibitor

SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SF1670, CAS 345630-40-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 90.00
10 mg	In stock	$ 127.00
25 mg	In stock	$ 287.00
50 mg	In stock	$ 527.00
100 mg	In stock	$ 779.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.54%

Purity: 98.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
Targets&IC50	PTEN:2 μM
In vitro	SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. [1] SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions. [2]
In vivo	Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia. [2]
Kinase Assay	PTEN Inhibition Assay: To determine the dose response of potential PTEN inhibitors, doses of test compounds ranging from 1 nM to 250 uM (final reaction mix concentrations) are evaluated in the general PTEN inhibition assay. To obtain performed IC50 data, two separate rounds of the dose response assay are performed. In the first round, PTEN activity is tested in the presence of inhibitor at 10 fold serial dilutions ranging from 1 nM to 250 uM. Once the concentration range is determined, at which PTEN activity changes dramatically, two additional concentration data points within this range are added and the PTEN inhibition assay is then rerun for the second round. The PTEN inhibition IC50 is presented as the inhibitor concentration at which 50% of the PTEN activity. When the assay was run on multiple occasions and gave slightly different IC50 then those are reported as a range of IC50 found.
Cell Research	Cells are plated into 96-well plates in RPMI 1640 medium supplemented with 10% FBS and incubated overnight at 37°C. in an incubator containing an atmosphere of 5% CO2. The following day, the medium is replaced and cells are starved by placing in 100 uL of serum-free medium for 3 hours. Serially diluted test compounds are added to the wells and incubated with the cells for 2 hours at 37°C. Compounds are tested in a range from 1 mM to 0.1 nM depending on solubility. MTT is added to the wells at a final concentration of 5 μg/ml and incubated with the cells for 3 more hours. At the end of the incubation, the medium is aspirated and the MTT stain in the cells is dissolved by the addition of 100 μL DMSO. Optical density of each well is then measured at 570 nm using a SpectroMax Plus spectrophotometric plate reader. The IC50 determination from the data was made using Prism software.(Only for Reference)

Synonyms	PTP CD45 Inhibitor, PTPase CD45 Inhibitor
Molecular Weight	307.34
Formula	C19H17NO3
CAS No.	345630-40-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.7 mg/mL (100 mM)

References and Literature

1. Garlich JR, et al. PCT/US2005/011626. 2. Li Y, et al. Blood. 2011, 17(24), 6702-6713. 3. Lian Z, Hu Z, Xian H, et al. Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression[J]. Chemosphere. 2020, 244: 125496

Citations

1. Lian Z, Hu Z, Xian H, et al. Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression. Chemosphere. 2020, 244: 125496

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Reprogramming Compound Library Bioactive Compounds Library Max Autophagy Compound Library Neuronal Differentiation Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Antidepressant Compound Library Phosphatase Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SF1670 345630-40-2 Autophagy Metabolism PI3K/Akt/mTOR signaling Phosphatase PTEN SF 1670 PTP CD45 Inhibitor inhibit MMAC1 Inhibitor PTPase CD45 Inhibitor Phosphatase and tensin homolog SF-1670 inhibitor

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