Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 37.00 | |
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 195.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 638.00 | |
500 mg | In stock | $ 1,330.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM). |
Targets&IC50 | MDMX:5 μM |
In vitro | SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates [1][2]. |
Molecular Weight | 428.87 |
Formula | C22H21ClN2O5 |
CAS No. | 431979-47-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (77.72 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SJ-172550 431979-47-4 Apoptosis Ubiquitination E1/E2/E3 Enzyme Mdm2 E3 ligating enzyme Ubiquitin activating enzyme E2 conjugating enzyme MDM-2/p53 Ubiquitin ligase E1 activating enzyme SJ 172550 inhibit Ubiquitin conjugating enzyme Inhibitor SJ172550 inhibitor