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SJ-172550

Catalog No. T16888   CAS 431979-47-4

SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).

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SJ-172550 Chemical Structure
SJ-172550, CAS 431979-47-4
Pack Size Availability Price/USD Quantity
2 mg In stock $ 37.00
5 mg In stock $ 59.00
10 mg In stock $ 97.00
25 mg In stock $ 195.00
50 mg In stock $ 372.00
100 mg In stock $ 638.00
500 mg In stock $ 1,330.00
1 mL * 10 mM (in DMSO) In stock $ 66.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
Targets&IC50 MDMX:5 μM
In vitro SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates [1][2].
Molecular Weight 428.87
Formula C22H21ClN2O5
CAS No. 431979-47-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (77.72 mM), sonification is recommended.

TargetMolReferences and Literature

1. Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96. 2. Bista M, et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-Cancer Metabolism Compound Library PPI Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Anti-Pancreatic Cancer Compound Library Anti-Aging Compound Library Anti-Colorectal Cancer Compound Library Anti-Lung Cancer Compound Library

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Keywords

SJ-172550 431979-47-4 Apoptosis Ubiquitination E1/E2/E3 Enzyme Mdm2 E3 ligating enzyme Ubiquitin activating enzyme E2 conjugating enzyme MDM-2/p53 Ubiquitin ligase E1 activating enzyme SJ 172550 inhibit Ubiquitin conjugating enzyme Inhibitor SJ172550 inhibitor

 

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