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SR18662

Catalog No. T22429   CAS T22429

SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis.

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SR18662 Chemical Structure
SR18662, CAS T22429
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 97.00
10 mg In stock $ 163.00
25 mg In stock $ 328.00
50 mg In stock $ 528.00
100 mg In stock $ 756.00
200 mg In stock $ 987.00
500 mg In stock $ 1,530.00
1 mL * 10 mM (in DMSO) In stock $ 107.00
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Purity: 96.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis.
Targets&IC50 KLF5:4.4 nM
In vitro SR18662 significantly reduces growth and proliferation of CRC cells and shows improved efficacy in reducing viability of multiple CRC cell lines. Flow cytometry analysis following SR18662 treatment shows an increase in cells captured in either S or G2/M phases of the cell cycle and a significant increase in the number of apoptotic cells. SR18662 also reduces the expression of cyclins and components of WNT and MAPK signaling pathways.[1]
In vivo The effect of SR18662 treatment shows a significant dose-dependent inhibition of xenograft growth in mice and exceeds ML264 at equivalent doses. SR18662 is potential for colorectal cancer therapy.[1]
Cell Research Cell lines: HT29, HCT116, DLD-1 and SW620 colorectal cancer cell lines. Concentrations: 0.001 μM-20 μM. Incubation Time: 24 h. Method: KLF5 promoter activity assay: DLD-1/pGL4.18hKLF5p cells are seeded in 96 well plate and treated with SR18662 dissolved in DMSO in the range of 0.001 to 20 μM or equivalent volume of DMSO as control for 24 h, the human KLF5 promoter activity is determined with the ONE-Glo luciferase assay system by a SpectramMax M3 plate reader.
Animal Research Animal Models: 7-week-old male NuJ/Foxn1nu mice with DLD-1 human colorectal cells injected. Dosages: 5 mg/kg, 10 mg/kg, 25 mg/kg. Administration: I.P.
Molecular Weight 420.31
Formula C16H19Cl2N3O4S
CAS No. T22429

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120mg/mL (285.50 mM)

TargetMolReferences and Literature

1. Julie Kim, et al. Mol Cancer Ther. 2019 Nov;18(11):1973-1984.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library DNA Damage & Repair Compound Library NO PAINS Compound Library Inhibitor Library Anti-Colorectal Cancer Compound Library Bioactive Compound Library Cell Cycle Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

SR18662 T22429 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis SR 18662 SR-18662 inhibitor inhibit

 

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