Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 328.00 | |
50 mg | In stock | $ 489.00 | |
100 mg | In stock | $ 713.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier. |
Targets&IC50 | HDAC6:2.3 nM, HDAC8:3.72 μM, HDAC1:5.23 μM, HDAC10:26.2 μM, HDAC11:5.72 μM, HDAC3:29.5 μM, HDAC5:4.07 μM, HDAC9:3.46 μM, HDAC7:4.55 μM, HDAC2:32.8 μM, HDAC4:10.9 μM |
In vitro | SW-100 (0.01-10 μM; 48 hours) shows obvious enhance in the acetylated α-tubulin levels in a dose-dependent manner [1]. |
In vivo | In mouse model of Fragile X syndrome, SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1]. |
Molecular Weight | 316.78 |
Formula | C17H17ClN2O2 |
CAS No. | 2126744-35-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (394.60 mM)
You can also refer to dose conversion for different animals. More
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SW-100 2126744-35-0 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Inhibitor SW 100 inhibit SW100 inhibitor