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Sarcosine

Catalog No. T6975 CAS 107-97-1

Synonyms: N-methylglycine, 肌氨酸, N-Methylaminoacetic acid, Methylaminoacetic acid, Sarcosinic acid, Methylglycine, Sarcosin

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

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Sarcosine, CAS 107-97-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
In vitro	Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4].
In vivo	Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3].
Cell Research	Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)

Synonyms	N-methylglycine, 肌氨酸, N-Methylaminoacetic acid, Methylaminoacetic acid, Sarcosinic acid, Methylglycine, Sarcosin
Molecular Weight	89.094
Formula	C3H7NO2
CAS No.	107-97-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Insoluble

H2O: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang HX, et al. Neuropharmacology. 57(5-6):551-5. 2. Socała K, et al. Pharmacol Rep. 2010, 62(2):392-7. 3. Chen HH, et al. Psychopharmacology (Berl). 2010, 209(4):343-50. 4. Sudhakaran P R , Binu S , Soumya S J . Effect of sarcosine on endothelial function relevant to angiogenesis.[J]. Journal of Cancer Research & Therapeutics, 2014, 10(3):603-610.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Gut Microbial Metabolite Library Anti-Cancer Metabolism Compound Library Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library Glutamine Metabolism Compound Library Inhibitor Library Natural Product Library for HTS

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Keywords

Sarcosine 107-97-1 代谢其他神经科学 Endogenous Metabolite GlyT Others inhibit dysfunction schizophrenia Sarcosin Methylglycine Methylaminoacetic acid N-Methylaminoacetic acid Sarcosinic acid Inhibitor cognitive depression N-methylglycine Glycine transporters inhibitor

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