Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Description | Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. |
In vitro | Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4]. |
In vivo | Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3]. |
Cell Research | Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference) |
Synonyms | N-methylglycine, 肌氨酸, N-Methylaminoacetic acid, Methylaminoacetic acid, Sarcosinic acid, Methylglycine, Sarcosin |
Molecular Weight | 89.094 |
Formula | C3H7NO2 |
CAS No. | 107-97-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: Insoluble
H2O: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Sarcosine 107-97-1 代谢 其他 神经科学 Endogenous Metabolite GlyT Others inhibit dysfunction schizophrenia Sarcosin Methylglycine Methylaminoacetic acid N-Methylaminoacetic acid Sarcosinic acid Inhibitor cognitive depression N-methylglycine Glycine transporters inhibitor