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Sarcosine

Catalog No. T6975   CAS 107-97-1
Synonyms: Sarcosinic acid, Methylaminoacetic acid, Sarcosin, Methylglycine, N-Methylaminoacetic acid, N-methylglycine

Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

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Sarcosine Chemical Structure
Sarcosine, CAS 107-97-1
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500 mg In stock $ 39.00
1 g In stock $ 55.00
5 g In stock $ 133.00
10 g In stock $ 198.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
In vitro Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4].
In vivo Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3].
Cell Research Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)
Synonyms Sarcosinic acid, Methylaminoacetic acid, Sarcosin, Methylglycine, N-Methylaminoacetic acid, N-methylglycine
Molecular Weight 89.09
Formula C3H7NO2
CAS No. 107-97-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

TargetMolReferences and Literature

1. Zhang HX, et al. Neuropharmacology. 57(5-6):551-5. 2. Socała K, et al. Pharmacol Rep. 2010, 62(2):392-7. 3. Chen HH, et al. Psychopharmacology (Berl). 2010, 209(4):343-50. 4. Sudhakaran P R , Binu S , Soumya S J . Effect of sarcosine on endothelial function relevant to angiogenesis.[J]. Journal of Cancer Research & Therapeutics, 2014, 10(3):603-610.

Related compound libraries

This product is contained In the following compound libraries:
Human Endogenous Metabolite Library Anti-Neurodegenerative Disease Compound Library Anti-Tumor Natural Product Library Human Metabolite Library Ion Channel Inhibitor Library Glutamine Metabolism Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Alzheimer's Disease Compound Library Natural Product Library for HTS ReFRAME Related Library

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Keywords

Sarcosine 107-97-1 Metabolism Neuroscience Others GlyT Endogenous Metabolite inhibit dysfunction schizophrenia Sarcosinic acid Methylaminoacetic acid Sarcosin Inhibitor Methylglycine cognitive depression N-Methylaminoacetic acid Glycine transporters N-methylglycine inhibitor

 

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