Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 96.00 | |
10 mg | In stock | $ 165.00 | |
25 mg | In stock | $ 319.00 | |
50 mg | In stock | $ 478.00 | |
100 mg | In stock | $ 687.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways. |
Targets&IC50 | MDA-MB-231 cell:29.7 μM (IC50) |
In vitro | Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner, and induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated 'intrinsic' pathway [1]. Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner (IC50: 29.7 μM) [2]. |
Source |
Synonyms | Kushenol F, Vexibinol |
Molecular Weight | 424.49 |
Formula | C25H28O6 |
CAS No. | 97938-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (58.89 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sophoraflavanone G 97938-30-2 Apoptosis Inhibitor anti-infammatory HL60 inhibit Kushenol F Vexibinol inhibitor