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TCS-OX2-29

Catalog No. T4965   CAS 372523-75-6

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays <250-fold selectivity for OX2 over OX1.

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TCS-OX2-29 Chemical Structure
TCS-OX2-29, CAS 372523-75-6
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 64.00
10 mg In stock $ 97.00
25 mg In stock $ 189.00
50 mg In stock $ 278.00
100 mg In stock $ 497.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 99.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
Targets&IC50 OX2 receptor:40 nM
In vitro TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuropeptide Y[1]. TCS-OX2-29 Inhibits orexin A-induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor[2].
Molecular Weight 397.51
Formula C23H31N3O3
CAS No. 372523-75-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (22.64 mM)

TargetMolReferences and Literature

1. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9. 2. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library GPCR Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max Inhibitor Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets
Filorexant MK-1064 Orexin 2 Receptor Agonist PF3274167 SB-408124 EMPA YNT-185 MK-3697

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Keywords

TCS-OX2-29 372523-75-6 GPCR/G Protein Neuroscience OX Receptor HCRT Receptor TCSOX229 inhibit Inhibitor Orexin Receptor (OX Receptor) Hypocretin Receptor TCS-OX-2-29 TCS OX2 29 inhibitor

 

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