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TH287

Catalog No. T2069 CAS 1609960-30-6

Synonyms: TH287 hydrochloride

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TH287, CAS 1609960-30-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 41.00
5 mg	In stock	$ 66.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 386.00
100 mg	In stock	$ 573.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99%

Purity: 97.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Targets&IC50	MTH1:0.8 nM
In vitro	TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]
In vivo	In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2]

Synonyms	TH287 hydrochloride
Molecular Weight	269.13
Formula	C11H10Cl2N4
CAS No.	1609960-30-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 10 mg/mL (37.15 mM), Heating is recommended.

DMSO: 49 mg/mL (160.3 mM)

References and Literature

1. Gad H, et al. Nature. 2014, 508(7495), 215-221. 2. Saleh A, et al. J Pharm Biomed Anal. 2015, 104, 1-11.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library NO PAINS Compound Library Toxic Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH287 1609960-30-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis MTH1 TH 287 Hydrochloride TH-287 inhibit TH 287 TH287 hydrochloride TH287 Hydrochloride TH-287 Hydrochloride Inhibitor inhibitor

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