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TIK-301

Catalog No. T17095 CAS 118702-11-7

Synonyms: PD-6735, LY-156735

TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.

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TIK-301, CAS 118702-11-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.
Targets&IC50	melatonin MT2:0.042 nM （ki）, melatonin MT1:0.081 nM （ki）

Synonyms	PD-6735, LY-156735
Molecular Weight	280.75
Formula	C14H17ClN2O2
CAS No.	118702-11-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TIK-301 118702-11-7 G蛋白偶联受体神经科学 5-HT Receptor LY-156735 TIK 301 PD-6735 TIK301 Inhibitor inhibitor inhibit

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