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Talabostat mesylate

Catalog No. T4042 CAS 150080-09-4

Synonyms: Val-boroPro, PT100

Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony-stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis.

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Talabostat mesylate, CAS 150080-09-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 159.00
50 mg	In stock	$ 397.00
1 mL * 10 mM (in DMSO)	In stock	$ 118.00

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Purity: 98%

Biological Description

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Description	Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony-stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis.
Targets&IC50	DPP4:0.18 nM

Synonyms	Val-boroPro, PT100
Molecular Weight	310.18
Formula	C10H23BN2O6S
CAS No.	150080-09-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (193.44 mM)

References and Literature

1. Cristillo AD, et al. HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with Talabostat. Biochem Biophys Res Commun. 2008 May 23;370(1):22-6. 2. Huang Y., et al. Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin Exp Metastasis. 2011 Aug;28(6):567-79. 3. Meany H, et al. Pediatric phase I trial design using maximum target inhibition as the primary endpoint. J Natl Cancer Inst. 2010 Jun 16;102(12):909-12.

Citations

1. Luo Y, Zeng Z, Shan T, et al. Fibroblast activation protein α activatable theranostic pro-photosensitizer for accurate tumor imaging and highly-specific photodynamic therapy. Theranostics. 2022, 12(8): 3610

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Pancreatic Cancer Compound Library Covalent Inhibitor Library Ubiquitination Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Talabostat mesylate 150080-09-4 Proteases/Proteasome Ubiquitination Proteasome DPP-4 inhibit Inhibitor Dipeptidyl Peptidase Val-boroPro Talabostat Mesylate PT-100 DPP PT100 PT 100 Talabostat inhibitor

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