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Tetracycline hydrochloride

Catalog No. T0912 CAS 64-75-5

Synonyms: NCI-c55561, Tetracycline HCl

Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

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Tetracycline hydrochloride Chemical Structure

Tetracycline hydrochloride, CAS 64-75-5

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500 mg	In stock	$ 41.00
1 g	In stock	$ 59.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.43%

Purity: 97.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
In vitro	Tetracyclines are versatile broad-spectrum antibiotics effective against a vast array of organisms, including gram-positive and gram-negative bacteria, as well as atypical pathogens like chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Their mechanism of action involves blocking bacterial protein synthesis by hindering the binding of aminoacyl-tRNA to the bacterial ribosome. Specifically, in gram-negative enteric bacteria, tetracyclines enter through OmpF and OmpC porin channels as positively charged coordination complexes, likely involving magnesium ([1]).
In vivo	Tetracyclines are utilized for managing infections in various livestock, including poultry, cattle, sheep, and swine, and in aquaculture species such as salmon, catfish, and lobsters[2]. In specific scenarios, such as treating large populations of commercially farmed poultry, these antibiotics may be administered directly through feed, water, or aerosols. Additionally, tetracyclines may serve to promote or enhance growth.

Synonyms	NCI-c55561, Tetracycline HCl
Molecular Weight	480.9
Formula	C22H24N2O8·HCl
CAS No.	64-75-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 89 mg/mL (185.1 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 88 mg/mL (183 mM)

References and Literature

1. Chopra I, et al.Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance.Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Microbial Natural Product Library Drug Repurposing Compound Library Bioactive Compounds Library Max Covalent Natural Product Library Anti-Bacterial Compound Library FDA-Approved & Pharmacopeia Drug Library Toxic Compound Library Orally Active Compound Library Approved Drug Library

Related Products

Related compounds with same targets

Oxytetracycline Acetylspiramycin Lincomycin hydrochloride Puromycin dihydrochloride Lincomycin hydrochloride monohydrate Dirithromycin Doxycycline (hyclate) Tobramycin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Tetracycline hydrochloride 64-75-5 Microbiology/Virology ribosome Antibiotic Antibacterial NCI-c55561 inhibit Tetracycline Tetracycline Hydrochloride Bacterial Tetracycline HCl Inhibitor inhibitor

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