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Tilmicosin

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Purity:98.15%

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COA HNMR LCMS

Tilmicosin

Catalog No. T0777Cas No. 108050-54-0

Tilmicosin (EL-870) is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.

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Pack Size	Price	Availability
500 mg	$47	In Stock
1 g	$68	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Product Introduction

Bioactivity

Description	Tilmicosin (EL-870) is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
In vivo	After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.[2]
Alias	LY-177370, EL-870

Chemical Properties

Molecular Weight	869.13
Formula	C46H80N2O13
Cas No.	108050-54-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 8 mg/mL (9.2 mM)

DMSO: 55 mg/mL (63.28 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.1506 mL	5.7529 mL	11.5058 mL	57.5288 mL
5 mM	0.2301 mL	1.1506 mL	2.3012 mL	11.5058 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1151 mL	0.5753 mL	1.1506 mL	5.7529 mL
20 mM	0.0575 mL	0.2876 mL	0.5753 mL	2.8764 mL
50 mM	0.0230 mL	0.1151 mL	0.2301 mL	1.1506 mL
100 mM	0.0115 mL	0.0575 mL	0.1151 mL	0.5753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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