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Toceranib

Catalog No. T13178   CAS 356068-94-5
Synonyms: PHA 291639E, SU11654

Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Toceranib Chemical Structure
Toceranib, CAS 356068-94-5
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 59.00
50 mg In stock $ 80.00
100 mg In stock $ 118.00
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Purity: 97.14%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.
Targets&IC50 PDGFRβ:5 nM (ki), Flk-1:6 nM (ki)
In vivo Administration of toceranib significantly decreased the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving toceranib and CYC demonstrated a significant increase in serum concentrations of IFN-γ, which was inversely correlated with Treg numbers after 6 weeks of combination treatment[1].
Synonyms PHA 291639E, SU11654
Molecular Weight 396.46
Formula C22H25FN4O2
CAS No. 356068-94-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.4 mg/mL (6.05 mM), sonification is recommended.

TargetMolReferences and Literature

1. Mitchell L, et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26(2):355-62. 2. Halsey CH, et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105. 3. London CA, et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9(7):2755-68.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Approved Drug Library Anti-Lung Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Angiogenesis related Compound Library Anti-Cancer Compound Library

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Keywords

Toceranib 356068-94-5 Angiogenesis Tyrosine Kinase/Adaptors VEGFR PDGFR c-Kit SCFR CD117 SU-11654 Vascular endothelial growth factor receptor inhibit Platelet-derived growth factor receptor Inhibitor PHA 291639E SU 11654 SU11654 inhibitor

 

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