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Tuxobertinib

Tuxobertinib
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, with KDs of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity.
Catalog No. T9072Cas No. 2414572-47-5
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Purity:98.86%
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Tuxobertinib

Purity: 98.86%
Catalog No. T9072Alias BDTX-189Cas No. 2414572-47-5

Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, with KDs of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity.
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Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
10 mg$58In Stock
25 mg$119In Stock
50 mg$223In Stock
100 mg$332In Stock
200 mg$475In Stock
1 mL x 10 mM (in DMSO)$41In Stock
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Product Introduction

Bioactivity
Description
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, with KDs of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity.
Targets&IC50
HER2:0.76 nM(KD), RIPK2:1.2 nM(KD), EGFR:0.2 nM(KD), BLK:13 nM(KD)
In vivo
BDTX-189 (0-100 mg/kg;?p.o.;?daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors.?BDTX-189 (1-50 mg/kg.p.o.;?daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV
AliasBDTX-189
Chemical Properties
Molecular Weight561.03
FormulaC29H29ClN6O4
Cas No.2414572-47-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 41.67 mg/mL (74.27 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7824 mL8.9122 mL17.8244 mL89.1218 mL
5 mM0.3565 mL1.7824 mL3.5649 mL17.8244 mL
10 mM0.1782 mL0.8912 mL1.7824 mL8.9122 mL
20 mM0.0891 mL0.4456 mL0.8912 mL4.4561 mL
50 mM0.0356 mL0.1782 mL0.3565 mL1.7824 mL

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