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UC-781
UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.
Catalog No. T29037Cas No. 178870-32-1
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Purity:92.17%
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UC-781
Catalog No. T29037Alias UC781, UC 781, NSC 675186Cas No. 178870-32-1
UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $191 | 6-8 weeks | |
| 25 mg | $1,130 | 6-8 weeks | |
| 50 mg | $1,480 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures. |
| Targets&IC50 | HIV-1:0.005 μM |
| In vitro | UC-781 (0.05, 0.2, and 0.5 % UC-781 supplemented gel; 10 days) is released from the gel formulation and clears HIV-1 from CEM cells [1]. UC-781 (3.75 -30 μM) inhibits the growth of Bacillus cereus (approximately 50%).[1] UC-781 inhibits HIV-1 (IIIB) activity in CEM T cells (EC50=6 nM; IC50=23 nM). UC-781 inhibits HIV activity in monocyte-derived dendritic cells (MO-DCs) and autologous CD4+ T cells with EC50 values of 550 nM and 1588 nM, respectively.[2] UC-781 (1000 nM; 24 h) effectively prevents or blocks HIV infection of monocyte-derived dendritic cells and autologous CD4+ T cells.[2] UC-781 (0.001-1000 µM; 2 h) inhibits viral transfer and infection of cervical explants with HIV-1BaL.[4] |
| In vivo | UC-781 (100 µl 5% UC-781 supplemented gel; intravaginally; once daily for 10 days; Female rabbit) is released from the gel formulation, exhibiting low toxicity to normal tissues in female rabbits with no significant increase in inflammatory cells.[1] |
| Alias | UC781, UC 781, NSC 675186 |
| Molecular Weight | 335.85 |
| Formula | C17H18ClNO2S |
| Cas No. | 178870-32-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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