Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 228.00 | |
100 mg | In stock | $ 372.00 | |
500 mg | In stock | $ 869.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. |
Targets&IC50 | BACE1:1.75 nM(Ki), BACE2:0.37 nM(Ki) |
In vitro | Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2]. |
In vivo | Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2]. |
Synonyms | MK-8931 |
Molecular Weight | 409.41 |
Formula | C17H17F2N5O3S |
CAS No. | 1286770-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (9.55 mM)
DMSO: 81 mg/mL (154.74 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Verubecestat 1286770-55-5 Neuroscience Beta-Secretase BACE MK-8931 orally Beta-secretase β-Secretase inhibit Aβ40 BACE1 Alzheimer's Inhibitor MK 8931 Disease BACE2 MK8931 inhibitor