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ZD-4190
🥰Excellent
Catalog No. T5475Cas No. 413599-62-9
ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment.
ZD-4190
🥰Excellent
Purity: 99.12%
Catalog No. T5475Cas No. 413599-62-9
ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $77 | In Stock | |
| 5 mg | $193 | In Stock | |
| 10 mg | $290 | In Stock | |
| 25 mg | $461 | In Stock | |
| 50 mg | $630 | In Stock | |
| 100 mg | $852 | In Stock | |
| 200 mg | $1,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $195 | In Stock |
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Purity:99.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment. |
| In vitro | ZD4190 can prevent outgrowth of malignant cells when the tumour burden is below a critical threshold. |
| In vivo | ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, [18F-FPPRGD2] uptake significantly decreased by 26.74 ± 8.12% (p<0.05) on day 1 and by 41.19 ± 6.63% (p<0.01) on day 3, returning to baseline by day 7. Tumor uptake of [18F-FLT] also decreased on days 1 and 3 after initiating ZD4190 treatment. However, ZD4190 did not significantly alter [18F-FDG] uptake compared to the control group. |
| Animal Research | ZD4190 was administered by gavage suspended in 1% polysorbate 80 at 50 mg/kg 24 h after tumour cell implantation for a maximum of 22 days. Control rodents were gavaged with the vehicle only and a third group was untreated. In preliminary experiments, rodents were killed on alternate days so that the effect of ZD4190 on tumour outgrowth could be assessed and subsequently the treatment response was evaluated at day 9 or 22. At least five rodents were included in each treatment group. |
| Molecular Weight | 459.27 |
| Formula | C19H16BrFN6O2 |
| Cas No. | 413599-62-9 |
| Smiles | COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20.83 mg/mL (45.35 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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