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Adenosine A1 receptor activator T62

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Catalog No. T14127Cas No. 40312-34-3

Adenosine A1 receptor activator T62 is an allosteric enhancer of the adenosine A1 receptor, producing antinociception in animal models of acute pain and reducing hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62

🥰Excellent
Purity: 95.00%
Catalog No. T14127Cas No. 40312-34-3
Adenosine A1 receptor activator T62 is an allosteric enhancer of the adenosine A1 receptor, producing antinociception in animal models of acute pain and reducing hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$193In Stock
10 mg$287In Stock
25 mg$463In Stock
50 mg$630In Stock
100 mg$852In Stock
200 mg$1,130In Stock
1 mL x 10 mM (in DMSO)$295In Stock
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Purity:95.00%
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Product Introduction

Bioactivity
Description
Adenosine A1 receptor activator T62 is an allosteric enhancer of the adenosine A1 receptor, producing antinociception in animal models of acute pain and reducing hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].
In vivo
Intrathecal administration of the adenosine A1 receptor activator T62 (0.3-3 μg) in male Sprague-Dawley rats produces a dose-dependent antihypersensitivity effect without affecting ambulation or activity levels[1].
Animal Research
Intrathecal T62 of Male SpragueDawley rats (250 g) after paw incision surgery with the dose of 0.3 μg, 0.5 μg, 1 μg, and 3 μg, produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) for T62 was 0.77 (0.63-0.91) microg.
Chemical Properties
Molecular Weight291.8
FormulaC15H14ClNOS
Cas No.40312-34-3
SmilesNc1sc2CCCCc2c1C(=O)c1ccc(Cl)cc1
Relative Density.1.337 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 75 mg/ml (257.03 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4270 mL17.1350 mL34.2700 mL171.3502 mL
5 mM0.6854 mL3.4270 mL6.8540 mL34.2700 mL
10 mM0.3427 mL1.7135 mL3.4270 mL17.1350 mL
20 mM0.1714 mL0.8568 mL1.7135 mL8.5675 mL
50 mM0.0685 mL0.3427 mL0.6854 mL3.4270 mL
100 mM0.0343 mL0.1714 mL0.3427 mL1.7135 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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