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AKN-028

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Catalog No. T38562Cas No. 1175017-90-9

AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.

AKN-028

AKN-028

🥰Excellent
Purity: 97.3%
Catalog No. T38562Cas No. 1175017-90-9
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Pack SizePriceAvailabilityQuantity
5 mg$53In Stock
10 mg$88In Stock
25 mg$187In Stock
50 mg$294In Stock
100 mg$429In Stock
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Purity:97.3%
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Product Introduction

Bioactivity
Description
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Targets&IC50
FGFR2:1200 nM (IC50), VEGFR2:520 nM (IC50), RPS6KA:220 nM (IC50), CLK1:140 nM (IC50), FLT3:6 nM (IC50)
In vitro
AKN-028 triggers apoptosis in MV4-11 by activation of caspase 3 [1] . AKN-028 (10 μM) is cytotoxic to AML cell lines and induces apoptosis in the AML cell line MV4-11 [1] . Cell Cytotoxicity Assay [1] Cell Line: AML cell line MV4-11. Concentration: 10 μM. Incubation Time: 24 h. Result: Was cytotoxic to primary AML cells, irrespective of FLT3 mutation status and quantitative FLT3 expression.
In vivo
AKN-028 (15?mg/kg, Subcutaneously injection twice daily) exhibits anti-tumor activities for acute myeloid leukemia (AML) models [1] . Animal Model: Mice based AML and MV4-11 cells [1] . Dosage: 15?mg/kg. Administration: Subcutaneously injection twice daily. Result: Inhibited net growth of one of the primary AML samples (UPN26) in vivo and furthermore reduced the tumor mass of MV4-11 cell line.
Chemical Properties
Molecular Weight302.33
FormulaC17H14N6
Cas No.1175017-90-9
SmilesN(C=1N=C(C=NC1N)C=2C=CN=CC2)C=3C=C4C(=CC3)NC=C4
Relative Density.1.405 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL 66.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3076 mL16.5382 mL33.0764 mL165.3822 mL
5 mM0.6615 mL3.3076 mL6.6153 mL33.0764 mL
10 mM0.3308 mL1.6538 mL3.3076 mL16.5382 mL
20 mM0.1654 mL0.8269 mL1.6538 mL8.2691 mL
50 mM0.0662 mL0.3308 mL0.6615 mL3.3076 mL

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