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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $79 | In Stock | |
10 mg | $123 | In Stock | |
25 mg | $239 | In Stock | |
50 mg | $378 | In Stock | |
100 mg | $559 | In Stock | |
500 mg | $1,190 | In Stock |
Description | ALK-IN-26 is an ALK inhibitor with potential anticancer activity, demonstrating antiproliferative effects against glioblastoma and inducing apoptosis, autophagy, and necrosis. |
In vitro | In GL261 cells, ALK-IN-26 (0.5 μM, 1.0 μM, 2.0 μM; 24 hours, 48 hours, 72 hours) induced apoptosis of glioblastoma in a concentration- and time-dependent manner, and resulted in cells (24.5%) entering the S phase when treated with 1 μM for 72 hours, but barely proceeding to the G2/M phase[1]. |
In vivo | In male C57BL/6J mice, ALK-IN-26 (5 mg/kg; i.v.; single dose) could be rapidly absorbed (Tmax = 0.58 hours) with an acceptable half-life (T1/2 = 3.55 hours) and bioavailability (F = 38.4%)[1]. |
Molecular Weight | 405.51 |
Formula | C24H23NO3S |
Cas No. | 2447607-85-2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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