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Almonertinib mesylate

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Purity:98.85%

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COA HNMR HPLC

Almonertinib mesylate

Catalog No. T9865Cas No. 2134096-06-1

Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.

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Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$197	In Stock
10 mg	$328	In Stock
25 mg	$558	In Stock
50 mg	$788	In Stock
100 mg	$1,120	In Stock
500 mg	$2,230	In Stock
1 mL x 10 mM (in DMSO)	$288	In Stock

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Product Introduction

Bioactivity

Description	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.
Targets&IC50	EGFR (T790M):0.37 nM, EGFR (del19/T790M):0.21 nM, EGFR (L858R/T790M):0.29 nM
In vitro	Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM)[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].

Chemical Properties

Molecular Weight	621.75
Formula	C31H39N7O5S
Cas No.	2134096-06-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (64.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6084 mL	8.0418 mL	16.0836 mL	80.4182 mL
5 mM	0.3217 mL	1.6084 mL	3.2167 mL	16.0836 mL
10 mM	0.1608 mL	0.8042 mL	1.6084 mL	8.0418 mL
20 mM	0.0804 mL	0.4021 mL	0.8042 mL	4.0209 mL
50 mM	0.0322 mL	0.1608 mL	0.3217 mL	1.6084 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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