Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $328 | In Stock | |
25 mg | $558 | In Stock | |
50 mg | $788 | In Stock | |
100 mg | $1,120 | In Stock | |
500 mg | $2,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $288 | In Stock |
Description | Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies. |
Targets&IC50 | EGFR (T790M):0.37 nM, EGFR (del19/T790M):0.21 nM, EGFR (L858R/T790M):0.29 nM |
In vitro | Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM)[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2]. |
Molecular Weight | 621.75 |
Formula | C31H39N7O5S |
Cas No. | 2134096-06-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (64.33 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.