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Alvespimycin

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Purity:100%

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COA HPLC HNMR

Alvespimycin

Catalog No. T20890Cas No. 467214-20-6

Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.

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Pack Size	Price	Availability
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$289	In Stock
50 mg	$428	In Stock
100 mg	$623	In Stock

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Product Introduction

Bioactivity

Description	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.
In vitro	After treatment with vehicle control or 1 μM Alvespimycin (17-DMAG) for 24 hours, CLL patient cells showed that Alvespimycin downregulated NF-κB signaling through IKKα and IKKβ[2].
In vivo	Treatment with vehicle (DMSO) or Alvespimycin(17-DMAG)(10 mg/kg) significantly prolonged the survival time of TCL1-SCID model mice[2].
Alias	17-DMAG, KOS1022, KOS 1022, KOS-1022

Chemical Properties

Molecular Weight	616.75
Formula	C32H48N4O8
Cas No.	467214-20-6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (129.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6214 mL	8.1070 mL	16.2140 mL	81.0701 mL
5 mM	0.3243 mL	1.6214 mL	3.2428 mL	16.2140 mL
10 mM	0.1621 mL	0.8107 mL	1.6214 mL	8.1070 mL
20 mM	0.0811 mL	0.4054 mL	0.8107 mL	4.0535 mL
50 mM	0.0324 mL	0.1621 mL	0.3243 mL	1.6214 mL
100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.8107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc