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AMPK-IN-3
🥰Excellent
Catalog No. T62745Cas No. 2417674-27-0
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.
AMPK-IN-3
🥰Excellent
Purity: 99.13%
Catalog No. T62745Cas No. 2417674-27-0
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $109 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $422 | In Stock | |
| 25 mg | $872 | In Stock | |
| 50 mg | $1,170 | In Stock | |
| 100 mg | $1,580 | In Stock |
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Purity:99.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells. |
| Targets&IC50 | AMPK α1:107 nM, AMPK α2:60.7 nM, KDR:3820 nM |
| In vitro | At a concentration of 100 nM, AMPK-IN-3 exhibits inhibition values of 64%, 43%, 41%, and 29% for AMPK(α2), FLT1, JAK1 JH2-pseudokinase, and AMPK(α1), respectively[1].In K562 cells, AMPK-IN-3, when applied at concentrations of 0.195313, 0.78125, 3.125, 12.5, and 50 µM for 2 hours, reduces the level of p-ACC[1]. For a duration of 24, 48, and 72 hours, AMPK-IN-3, within the concentration range of 1-100 µM, demonstrates potent inhibition of cellular AMPK activity without affecting cell viability[1]. |
| Molecular Weight | 451.56 |
| Formula | C25H33N5O3 |
| Cas No. | 2417674-27-0 |
| Smiles | CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC(N)=O)cc23)c1C |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (110.73 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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