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Antazoline hydrochloride

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Purity:99.76%

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COA LCMS HPLC HNMR

Antazoline hydrochloride

Catalog No. T0092Cas No. 2508-72-7

Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.

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Pack Size	Price	Availability
50 mg	$42	In Stock
100 mg	$59	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.
In vitro	In the model of sustained epileptic state induced by picrotoxin, Antazoline can be utilized to protect the intrinsic neural circuitry.
In vivo	At a concentration of 30 μM, Antazoline effectively reduces neurotoxicity mediated by NMDA and also blocks NMDA-induced currents via a voltage-dependent and rapidly reversible action, with an inhibition rate of 85±3% at a voltage of -60 mV.
Alias	Phenazocine HCl, Phenazoline hydrochloride, Antazoline HCl

Chemical Properties

Molecular Weight	301.82
Formula	C17H19N3·HCl
Cas No.	2508-72-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (149.1 mM)

H2O: 14 mg/mL (46.38 mM)

Ethanol: 4 mg/mL (13.25 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.3132 mL	16.5662 mL	33.1323 mL	165.6617 mL
5 mM	0.6626 mL	3.3132 mL	6.6265 mL	33.1323 mL
10 mM	0.3313 mL	1.6566 mL	3.3132 mL	16.5662 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1657 mL	0.8283 mL	1.6566 mL	8.2831 mL
50 mM	0.0663 mL	0.3313 mL	0.6626 mL	3.3132 mL
100 mM	0.0331 mL	0.1657 mL	0.3313 mL	1.6566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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