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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $84 | In Stock | |
10 mg | $139 | In Stock | |
25 mg | $233 | In Stock | |
50 mg | $347 | In Stock | |
100 mg | $516 | In Stock | |
500 mg | $1,090 | In Stock |
Description | Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in rats. |
In vitro | Anticancer agent 43 (compound 3a) selectively targets human tumor cells, exhibiting an SI50 of 28.94[1]. In HepG2 cells treated with 45 µM for 24 hours, it induces apoptosis via caspase 3, PARP1, and Bax-dependent pathways without affecting the G1/S phase transition[1]. It also causes DNA damage in HCT116, MCF-7, HepG2, and Balb/c 3T3 cells at concentrations of 0.7, 45, and 55 µM, as evidenced by tail DNA and Olive Tail Moment (OTM) measurements[1]. |
Molecular Weight | 336.36 |
Formula | C14H9FN2O3S2 |
Cas No. | 2470015-35-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (297.30 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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