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Arglabin

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Purity:99.62%

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COA HPLC HNMR

Arglabin

Catalog No. TQ0165Cas No. 84692-91-1

Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

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Pack Size	Price	Availability
1 mg	$106	In Stock
5 mg	$253	In Stock
10 mg	$379	In Stock
25 mg	$547	In Stock
50 mg	$728	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$327	In Stock

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Product Introduction

Bioactivity

Description	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
In vitro	Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 μg/mL and 0.125 μg/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells [1]. Arglabin exhibits anti exudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma [2]. Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells [3].
Alias	(+)-Arglabin

Chemical Properties

Molecular Weight	246.3
Formula	C15H18O3
Cas No.	84692-91-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (385.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	203.0045 mL
5 mM	0.8120 mL	4.0601 mL	8.1202 mL	40.6009 mL
10 mM	0.4060 mL	2.0300 mL	4.0601 mL	20.3004 mL
20 mM	0.2030 mL	1.0150 mL	2.0300 mL	10.1502 mL
50 mM	0.0812 mL	0.4060 mL	0.8120 mL	4.0601 mL
100 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0300 mL

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In Vivo Formulation Calculator (Clear solution)

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