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Arnicolide D

Arnicolide D
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
Catalog No. TN1405Cas No. 34532-68-8
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Purity:96.66%
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Arnicolide D

Catalog No. TN1405Cas No. 34532-68-8

Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
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Pack SizePriceAvailabilityQuantity
1 mg$155In Stock
5 mg$473In Stock
10 mg$679In Stock
25 mg$987In Stock
50 mg$1,380In Stock
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Product Introduction

Bioactivity
Description
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
In vitro
In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and Arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin.
Chemical Properties
Molecular Weight332.39
FormulaC19H24O5
Cas No.34532-68-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2.75 mg/mL (8.27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0085 mL15.0426 mL30.0851 mL150.4257 mL
5 mM0.6017 mL3.0085 mL6.0170 mL30.0851 mL

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