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AZD-8529 mesylate
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AZD-8529 mesylate
Catalog No. T10432LCas No. 1314217-69-0
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $178 | In Stock | |
| 10 mg | $289 | In Stock | |
| 25 mg | $578 | In Stock | |
| 50 mg | $833 | In Stock | |
| 100 mg | $1,150 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $232 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
| In vitro | AZD-8529 potentiates the effects of glutamate at mGluR2 (EC50: 195 nM). It does not elicit antagonist responses on mGluRs at 25 μM. |
| In vivo | AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats. AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. |
| Molecular Weight | 583.58 |
| Formula | C25H28F3N5O6S |
| Cas No. | 1314217-69-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.67 mg/mL (71.40 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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