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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $55 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $163 | In Stock | |
50 mg | $263 | In Stock | |
100 mg | $422 | In Stock | |
1 mL x 10 mM (in DMSO) | $61 | In Stock |
Description | AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit. |
In vitro | In the C6 rat glioma model, oral administration of AZD2932 (12.5 or 50 mg/kg, b.i.d.) was able to inhibit tumor growth. Additionally, in xenografts with tumors not expressing PDGFβ, oral doses of AZD2932 (50 mg/kg, b.i.d.) succeeded in suppressing the growth of Calu-6 and LoVo tumors. |
In vivo | AZD2932 effectively inhibits the phosphorylation of PDGFRα and PDGFRβ, demonstrating strong activity against a variety of receptors including VEGFR-2 (IC50=8 nM), PDGFRβ (IC50=4 nM), Flt-3 (IC50=7 nM), and c-Kit (IC50=9 nM). |
Kinase Assay | Kinase Assays : In vitro kinase IC50 values are measured using 33P filtration binding assay after 1 hour incubation of kinase, 33P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology. |
Molecular Weight | 447.49 |
Formula | C24H25N5O4 |
Cas No. | 883986-34-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 82 mg/mL (183.2 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 5 mg/mL (11.17 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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