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AZD3839 free base

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Purity:99.96%

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COA HPLC HNMR

AZD3839 free base

Catalog No. T6772Cas No. 1227163-84-9

AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]

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Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$68	In Stock
5 mg	$116	In Stock
10 mg	$178	In Stock
25 mg	$363	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Product Introduction

Bioactivity

Description	AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]
Targets&IC50	BACE1:26.1 nM(Ki)
In vitro	In SH-SY5Y cells, AZD3839 efficiently decreases the Aβ40 levels with IC50 of 4.8 nM, and decreases the formation of sAPPβ with IC50 of 16.7 nM. AZD3839 also decreases the Aβ40 levels secreted from C57BL/6 mouse primary cortical neurons, N2A cells, and Dunkin-Hartley guinea pig primary cortical neurons with IC50 values of 50.9, 32.2, and 24.8 nM, respectively. [1] AZD3839 causes in vitro BACE1 inhibition in the cell assay with IC50 value of 16.7 nM. [2]
In vivo	In C57BL/6 mice, AZD3839 (69 mg/kg, p.o.) causes a dose- and time-dependent reduction of plasma and brain Aβ. In guinea pig and non-human primates, AZD3839 also inhibits Aβ generation. [1]
Alias	AZD3839

Chemical Properties

Molecular Weight	431.41
Formula	C24H16F3N5
Cas No.	1227163-84-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (185.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 80 mg/mL (185.4 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.3180 mL	11.5899 mL	23.1798 mL	115.8990 mL
5 mM	0.4636 mL	2.3180 mL	4.6360 mL	23.1798 mL
10 mM	0.2318 mL	1.1590 mL	2.3180 mL	11.5899 mL
20 mM	0.1159 mL	0.5795 mL	1.1590 mL	5.7950 mL
50 mM	0.0464 mL	0.2318 mL	0.4636 mL	2.3180 mL
100 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1590 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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