Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 152.00 | |
5 mg | In stock | $ 378.00 | |
10 mg | In stock | $ 563.00 | |
25 mg | In stock | $ 890.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,670.00 | |
500 mg | In stock | $ 3,350.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 429.00 |
Description | BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research. |
Targets&IC50 | BCAT2:153 nM, BCAT1:31 nM |
In vitro | BAY-069, inhibits the proliferation of U-87 and MDA-MB-231 cells. The compound is tested at concentrations ranging from 70 nM to 50 μM, with a duration of 72 hours. In U-87 cells, the IC50 is determined to be 358 nM, while in MDA-MB-231 cells, the IC50 is 874 nM [1]. |
In vivo | BAY-069 demonstrates high metabolic stability when incubated with human liver microsomes, with a blood clearance of 0.11 L/h/kg. It also shows moderate metabolic stability when incubated with rat hepatocytes, with a blood clearance of 1.8 L/h/kg. BAY-069 exhibits high permeability through Caco-2 cell monolayers without any signs of efflux [1]. |
Molecular Weight | 446.81 |
Formula | C22H14ClF3N2O3 |
CAS No. | 2639638-66-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (61.55 mM)
You can also refer to dose conversion for different animals. More
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BAY-069 2639638-66-5 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species BAY 069 BAY069 inhibitor inhibit