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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $152 | In Stock | |
5 mg | $378 | In Stock | |
10 mg | $563 | In Stock | |
25 mg | $890 | In Stock | |
50 mg | $1,230 | In Stock | |
100 mg | $1,670 | In Stock | |
500 mg | $3,350 | In Stock | |
1 mL x 10 mM (in DMSO) | $429 | In Stock |
Description | BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research. |
Targets&IC50 | BCAT2:153 nM, BCAT1:31 nM |
In vitro | BAY-069, inhibits the proliferation of U-87 and MDA-MB-231 cells. The compound is tested at concentrations ranging from 70 nM to 50 μM, with a duration of 72 hours. In U-87 cells, the IC50 is determined to be 358 nM, while in MDA-MB-231 cells, the IC50 is 874 nM [1]. |
In vivo | BAY-069 demonstrates high metabolic stability when incubated with human liver microsomes, with a blood clearance of 0.11 L/h/kg. It also shows moderate metabolic stability when incubated with rat hepatocytes, with a blood clearance of 1.8 L/h/kg. BAY-069 exhibits high permeability through Caco-2 cell monolayers without any signs of efflux [1]. |
Molecular Weight | 446.81 |
Formula | C22H14ClF3N2O3 |
Cas No. | 2639638-66-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (61.55 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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