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BAY-069

Catalog No. T67927Cas No. 2639638-66-5

BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.

BAY-069

BAY-069

Purity: 98.83%
Catalog No. T67927Cas No. 2639638-66-5
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.
Pack SizePriceAvailabilityQuantity
1 mg$152In Stock
5 mg$378In Stock
10 mg$563In Stock
25 mg$890In Stock
50 mg$1,230In Stock
100 mg$1,670In Stock
500 mg$3,350In Stock
1 mL x 10 mM (in DMSO)$429In Stock
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Purity:98.83%
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Product Introduction

Bioactivity
Description
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.
Targets&IC50
BCAT1:31 nM, BCAT2:153 nM
In vitro
BAY-069, inhibits the proliferation of U-87 and MDA-MB-231 cells. The compound is tested at concentrations ranging from 70 nM to 50 μM, with a duration of 72 hours. In U-87 cells, the IC50 is determined to be 358 nM, while in MDA-MB-231 cells, the IC50 is 874 nM [1].
In vivo
BAY-069 demonstrates high metabolic stability when incubated with human liver microsomes, with a blood clearance of 0.11 L/h/kg. It also shows moderate metabolic stability when incubated with rat hepatocytes, with a blood clearance of 1.8 L/h/kg. BAY-069 exhibits high permeability through Caco-2 cell monolayers without any signs of efflux [1].
Chemical Properties
Molecular Weight446.81
FormulaC22H14ClF3N2O3
Cas No.2639638-66-5
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (61.55 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2381 mL11.1904 mL22.3809 mL111.9044 mL
5 mM0.4476 mL2.2381 mL4.4762 mL22.3809 mL
10 mM0.2238 mL1.1190 mL2.2381 mL11.1904 mL
20 mM0.1119 mL0.5595 mL1.1190 mL5.5952 mL
50 mM0.0448 mL0.2238 mL0.4476 mL2.2381 mL

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