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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $350 | In Stock | |
5 mg | $828 | In Stock | |
10 mg | $1,130 | In Stock | |
25 mg | $1,590 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock | |
500 mg | $4,900 | In Stock |
Description | Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD). |
In vitro | Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase.[5] AG1717 (2 μM) inhibits the binding of integrase to substrate DNA.[5] |
In vivo | Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) improves proteinuria by altering actin kinetics.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) ameliorates or prevents proteinuria and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6] |
Alias | Bis T-23, Bis-T 23, AG1717 |
Molecular Weight | 480.43 |
Formula | C23H20N4O8 |
Cas No. | 171674-76-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | H2O: Insoluble ![]() DMSO: 12.01 mg/ml (25 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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