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Bis-T-23
🥰Excellent
Catalog No. T30479Cas No. 171674-76-3
Alias Bis-T 23, Bis T-23, AG1717
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
Bis-T-23
🥰Excellent
Purity: 98.77%
Catalog No. T30479Alias Bis-T 23, Bis T-23, AG1717Cas No. 171674-76-3
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $289 | In Stock | |
| 5 mg | $685 | In Stock | |
| 10 mg | $936 | In Stock | |
| 25 mg | $1,450 | In Stock | |
| 50 mg | $1,950 | In Stock | |
| 100 mg | $2,500 | In Stock |
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CitedSelect Batch
Purity:98.77%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD). |
| In vitro | Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase and, at a concentration of 2 μM, AG1717 also inhibits the binding of integrase to substrate DNA.[5] |
| In vivo | Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function. Bis-T-23 (i.p.; 20, 40 mg/kg) improves proteinuria by altering actin kinetics and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6] |
| Alias | Bis-T 23, Bis T-23, AG1717 |
| Molecular Weight | 480.43 |
| Formula | C23H20N4O8 |
| Cas No. | 171674-76-3 |
| Smiles | C(=C(/C(NCCCNC(/C(=C/C1=CC(O)=C(O)C(O)=C1)/C#N)=O)=O)\C#N)\C2=CC(O)=C(O)C(O)=C2 |
| Relative Density. | 1.582 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble  DMSO: 12.01 mg/ml (25 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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