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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $88 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $322 | In Stock | |
25 mg | $579 | In Stock | |
50 mg | $787 | In Stock | |
100 mg | $1,060 | In Stock | |
1 mL x 10 mM (in DMSO) | $235 | In Stock |
Description | BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator. |
In vitro | BMS-191095 elicits a dose-dependent vasodilation in endothelium-denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. BMS-191095 induces mitochondrial-depolarization and vasodilation. |
In vivo | In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels. |
Molecular Weight | 408.88 |
Formula | C22H21ClN4O2 |
Cas No. | 166095-21-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (220.11 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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