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BMS-191095

BMS-191095
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Purity:100%
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BMS-191095

Catalog No. T10566Cas No. 166095-21-2
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
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Pack SizePriceAvailabilityQuantity
1 mg$88In Stock
5 mg$213In Stock
10 mg$322In Stock
25 mg$579In Stock
50 mg$787In Stock
100 mg$1,060In Stock
1 mL x 10 mM (in DMSO)$235In Stock
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Product Introduction

Bioactivity
Description
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
In vitro
BMS-191095 elicits a dose-dependent vasodilation in endothelium-denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. BMS-191095 induces mitochondrial-depolarization and vasodilation.
In vivo
In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
Chemical Properties
Molecular Weight408.88
FormulaC22H21ClN4O2
Cas No.166095-21-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (220.11 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4457 mL12.2285 mL24.4571 mL122.2853 mL
5 mM0.4891 mL2.4457 mL4.8914 mL24.4571 mL
10 mM0.2446 mL1.2229 mL2.4457 mL12.2285 mL
20 mM0.1223 mL0.6114 mL1.2229 mL6.1143 mL
50 mM0.0489 mL0.2446 mL0.4891 mL2.4457 mL
100 mM0.0245 mL0.1223 mL0.2446 mL1.2229 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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