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BMS-345541 hydrochloride is a selective IKK inhibitor, targeting IKK2 and IKK1 with IC50 values of 0.3 μM and 4 μM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $79 | In Stock | |
10 mg | $128 | In Stock | |
25 mg | $236 | In Stock | |
50 mg | $396 | In Stock | |
100 mg | $593 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | BMS-345541 hydrochloride is a selective IKK inhibitor, targeting IKK2 and IKK1 with IC50 values of 0.3 μM and 4 μM, respectively. |
Targets&IC50 | IKK1:4 μM, IKK2:0.3 μM |
In vitro | BMS-345541 down-regulation of IKK activity results in mitochondria-mediated apoptosis of tumor cells because the programmed cell death machinery in melanoma cells is highly regulated by NF-kappaB signaling. Therefore, IKK may serve as a potential target for melanoma therapy[1]. |
Molecular Weight | 291.78 |
Formula | C14H18ClN5 |
Cas No. | 547757-23-3 |
Smiles | Cl.Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 18 mg/mL (61.69 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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