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Brinzolamide

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Catalog No. T0142Cas No. 138890-62-7
Alias AL-4862

Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. Its mechanism of action involves inhibiting the enzyme Carbonic Anhydrase.

Brinzolamide

Brinzolamide

🥰Excellent
Purity: 100%
Catalog No. T0142Alias AL-4862Cas No. 138890-62-7
Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. Its mechanism of action involves inhibiting the enzyme Carbonic Anhydrase.
Pack SizePriceAvailabilityQuantity
10 mg$30In Stock
25 mg$58In Stock
50 mg$89In Stock
100 mg$130In Stock
500 mg$272In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. Its mechanism of action involves inhibiting the enzyme Carbonic Anhydrase.
Targets&IC50
CA II:3.19 nM
In vitro
A 0.6 mg dose of Brinzolamide ophthalmic suspension reduces intraocular pressure in a dose-dependent manner in cynomolgus monkeys post-laser glaucoma surgery. Similarly, it lowers intraocular pressure in Dutch belted rabbits. Dosages of 1 mg/kg, 10 mg/kg, and 30 mg/kg of Brinzolamide prolong the sleep time induced by barbital in male CD-1 mice by 57%, 15%, and 35%, respectively. Less than 3% of Brinzolamide significantly increases both the percentage reduction and the mean decrease in intraocular pressure among patients with primary open-angle glaucoma or ocular hypertension compared to a placebo group. Additionally, a 2% Brinzolamide solution enhances optic nerve head blood flow and reduces intraocular pressure in resting Dutch belted rabbits.
AliasAL-4862
Chemical Properties
Molecular Weight383.51
FormulaC12H21N3O5S3
Cas No.138890-62-7
SmilesO=S1(=O)C2=C([C@@H](NCC)CN1CCCOC)C=C(S(N)(=O)=O)S2
Relative Density.1.50 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (156.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6075 mL13.0375 mL26.0749 mL130.3747 mL
5 mM0.5215 mL2.6075 mL5.2150 mL26.0749 mL
10 mM0.2607 mL1.3037 mL2.6075 mL13.0375 mL
20 mM0.1304 mL0.6519 mL1.3037 mL6.5187 mL
50 mM0.0521 mL0.2607 mL0.5215 mL2.6075 mL
100 mM0.0261 mL0.1304 mL0.2607 mL1.3037 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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