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Bufalin

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Purity:99.25%

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COA HPLC HNMR

Bufalin

Catalog No. T1719Cas No. 465-21-4

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

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Pack Size	Price	Availability
5 mg	$55	In Stock
10 mg	$80	In Stock
25 mg	$133	In Stock
50 mg	$197	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic a
Targets&IC50	Na+, K+-ATPase α3:40 nM (Kd), Na+, K+-ATPase α1:42.5 nM (Kd), Na+, K+-ATPase α2:45 nM (Kd)

Chemical Properties

Molecular Weight	386.52
Formula	C24H34O4
Cas No.	465-21-4

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (129.36 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5872 mL	12.9359 mL	25.8719 mL	129.3594 mL
5 mM	0.5174 mL	2.5872 mL	5.1744 mL	25.8719 mL
10 mM	0.2587 mL	1.2936 mL	2.5872 mL	12.9359 mL
20 mM	0.1294 mL	0.6468 mL	1.2936 mL	6.4680 mL
50 mM	0.0517 mL	0.2587 mL	0.5174 mL	2.5872 mL
100 mM	0.0259 mL	0.1294 mL	0.2587 mL	1.2936 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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