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Canertinib dihydrochloride
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Canertinib dihydrochloride
Catalog No. T2501Cas No. 289499-45-2
Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $32 | In Stock | |
| 10 mg | $48 | In Stock | |
| 50 mg | $68 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $47 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. |
| Kinase Assay | Kinase inhibition: Cediranib is dissolved in DMSO at a concentration of 10 mM. All enzyme assays are run at, or just below, the respective Km for ATP (0.2 - 30 μM). The inhibitory activity of Cediranib is determined against a range of recombinant tyrosine kinases [KDR, Flt-1, Flt-4, c-Kit, PDGFRα, PDGFRβ, CSF-1R, Flt-3, FGFR1, Src, Abl, epidermal growth factor receptor (EGFR), ErbB2, Aurora A, and Aurora B] using ELISA. Selectivity versus CDK2 and CDK4 serine/threonine kinases is examined using scintillation proximity assays with a retinoblastoma substrate and [γ-sup>33P]ATP. Activity of Cediranib is compared to MAPK kinase (MEK), which shows dual specificity. It is determined using a MAPK substrate, [γ-33P]ATP, and paper capture/scintillation counting. |
| Alias | CI-1033 dihydrochloride, PD-183805 dihydrochloride, Canertinib |
| Molecular Weight | 558.86 |
| Formula | C24H27Cl3FN5O3 |
| Cas No. | 289499-45-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55.9 mg/mL(100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Keywords
ErbB-1PD 183805PD 183805 DihydrochlorideOrthopoxvirusPD-183805EGFRCanertinib dihydrochlorideCI 1033 DihydrochloridePD183805 DihydrochloridePD183805CI1033 DihydrochlorideEpidermal growth factor receptorCI 1033PD-183805 DihydrochlorideInhibitorCI1033inhibitHER1CI-1033Canertinib DihydrochlorideCI-1033 Dihydrochloride
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