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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $105 | In Stock | |
10 mg | $172 | In Stock | |
25 mg | $363 | In Stock | |
50 mg | $578 | In Stock | |
100 mg | $828 | In Stock | |
500 mg | $1,690 | In Stock |
Description | CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration. |
In vitro | CJJ300 (20, 40, and 80 µM, 2 h; Human A549 lung epithelial cells) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. Downregulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2 in a dose-dependent manner without cytotoxicity. CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM). CJJ300 suppresses TGF-β induced cell migration.[1] |
Molecular Weight | 435.6 |
Formula | C30H33N3 |
Cas No. | 1807631-83-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 16.67 mg/mL (38.26 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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