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Columbianadin

🥰Excellent
Catalog No. T3373Cas No. 5058-13-9
Alias Zosimin, 2-Butenoic acid

Columbianadin (Zosimin), one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies.

Columbianadin

Columbianadin

🥰Excellent
Purity: 98.44%
Catalog No. T3373Alias Zosimin, 2-Butenoic acidCas No. 5058-13-9
Columbianadin (Zosimin), one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies.
Pack SizePriceAvailabilityQuantity
10 mg$60In Stock
20 mg$100In Stock
1 mL x 10 mM (in DMSO)$60In Stock
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Purity:98.44%
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Product Introduction

Bioactivity
Description
Columbianadin (Zosimin), one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies.
Kinase Assay
Cells are treated with various concentrations of Dihydrotanshinone I (3.13-20 μM) for 48 h. For the activity assay, Ac-DEVD-AMC (1 μg/μL), Ac-IETD-AMC (1 μg/μL) or Ac-LEDH-AMC (1 μg/μL) and cell lysate are added into Protease Assay Buffer in 96-well plate. Reaction mixtures with lysis buffer are used as negative controls. Cells treated with DMSO (0.1%) are treated as vehicle control. The reaction mixtures are incubated for 1 h at 37°C. The AMC liberated from the substrates is measured using spectrofluorometer of Victor 2 plate reader with an excitation wavelength of 380 nm and an emission wavelength of 430 nm.
AliasZosimin, 2-Butenoic acid
Chemical Properties
Molecular Weight328.36
FormulaC19H20O5
Cas No.5058-13-9
SmilesC\C=C(\C)C(=O)OC(C)(C)[C@@H]1Cc2c(O1)ccc1ccc(=O)oc21
Relative Density.1.232 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Chloroform: Soluble
DMSO: 59 mg/mL (179.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0454 mL15.2272 mL30.4544 mL152.2719 mL
5 mM0.6091 mL3.0454 mL6.0909 mL30.4544 mL
10 mM0.3045 mL1.5227 mL3.0454 mL15.2272 mL
20 mM0.1523 mL0.7614 mL1.5227 mL7.6136 mL
50 mM0.0609 mL0.3045 mL0.6091 mL3.0454 mL
100 mM0.0305 mL0.1523 mL0.3045 mL1.5227 mL

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