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Conoidin A

🥰Excellent
Catalog No. T21687Cas No. 18080-67-6

Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.

Conoidin A

Conoidin A

🥰Excellent
Purity: 98.00%
Catalog No. T21687Cas No. 18080-67-6
Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.
Pack SizePriceAvailabilityQuantity
10 mgInquiryIn Stock
25 mg40 €In Stock
50 mg57 €In Stock
1 mL x 10 mM (in DMSO)42 €In Stock
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Purity:98.00%
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Product Introduction

Bioactivity
Description
Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.
Targets&IC50
TgPrxII:23 µM (IC50)
Chemical Properties
Molecular Weight347.99
FormulaC10H8Br2N2O2
Cas No.18080-67-6
Smiles[O-][n+]1c(CBr)c(CBr)[n+]([O-])c2ccccc12
Relative Density.1.95 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 14.29 mg/mL (41.06 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8736 mL14.3682 mL28.7365 mL143.6823 mL
5 mM0.5747 mL2.8736 mL5.7473 mL28.7365 mL
10 mM0.2874 mL1.4368 mL2.8736 mL14.3682 mL
20 mM0.1437 mL0.7184 mL1.4368 mL7.1841 mL

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