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Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | In Stock | |
25 mg | 40 € | In Stock | |
50 mg | 57 € | In Stock | |
1 mL x 10 mM (in DMSO) | 42 € | In Stock |
Description | Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease. |
Targets&IC50 | TgPrxII:23 µM (IC50) |
Molecular Weight | 347.99 |
Formula | C10H8Br2N2O2 |
Cas No. | 18080-67-6 |
Smiles | [O-][n+]1c(CBr)c(CBr)[n+]([O-])c2ccccc12 |
Relative Density. | 1.95 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 14.29 mg/mL (41.06 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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