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CWI1-2

CWI1-2
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CWI1-2

Catalog No. T67930Cas No. 2408590-36-1
CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$105In Stock
10 mg$178In Stock
25 mg$396In Stock
50 mg$645In Stock
100 mg$987In Stock
500 mg$1,980In Stock
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Product Introduction

Bioactivity
Description
CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
In vitro
CWI1-2 demonstrates excellent anti-leukemia efficacy in a concentration range of 0-1 μM for 24 hours[1].
In vivo
Administered intravenously at 5 mg/kg once daily for 7-10 days, CWI1-2 significantly delays the onset of leukemia and extends the survival time in BMT (bone marrow transplantation) recipient B6.SJL (CD45.1) mice, with no apparent impact on body weight[1].
Chemical Properties
Molecular Weight519.77
FormulaC22H17Cl3N6O3
Cas No.2408590-36-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90 mg/mL (173.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9239 mL9.6196 mL19.2393 mL96.1964 mL
5 mM0.3848 mL1.9239 mL3.8479 mL19.2393 mL
10 mM0.1924 mL0.9620 mL1.9239 mL9.6196 mL
20 mM0.0962 mL0.4810 mL0.9620 mL4.8098 mL
50 mM0.0385 mL0.1924 mL0.3848 mL1.9239 mL
100 mM0.0192 mL0.0962 mL0.1924 mL0.9620 mL

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