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DG172 dihydrochloride

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Purity:100%

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COA LCMS HNMR

DG172 dihydrochloride

Catalog No. T7821Cas No. 1361504-77-9

DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$322	In Stock
100 mg	$522	In Stock

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Product Introduction

Bioactivity

Description	DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
In vitro	DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1].
Alias	DG172 (dihydrochloride), DG-172 dihydrochloride

Chemical Properties

Molecular Weight	455.2
Formula	C20H22BrCl2N3
Cas No.	1361504-77-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 14.29 mg/mL (31.39 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0439 mL	0.2197 mL	0.4394 mL	2.1968 mL
100 mM	0.0220 mL	0.1098 mL	0.2197 mL	1.0984 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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