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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $58 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $157 | In Stock | |
50 mg | $237 | In Stock | |
100 mg | $341 | In Stock | |
500 mg | $714 | In Stock | |
1 mL x 10 mM (in DMSO) | $56 | In Stock |
Description | DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
Targets&IC50 | DHODH:5.03(pKa) |
In vitro | A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure. |
Molecular Weight | 265.27 |
Formula | C15H11N3O2 |
Cas No. | 1263303-95-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (94.24 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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