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DL-Laudanosine
🥰Excellent
Catalog No. T8175Cas No. 1699-51-0
DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.
DL-Laudanosine
🥰Excellent
Purity: 99.79%
Catalog No. T8175Cas No. 1699-51-0
DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $42 | In Stock | |
| 10 mg | $59 | In Stock | |
| 25 mg | $93 | In Stock | |
| 50 mg | $135 | In Stock | |
| 100 mg | $197 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock |
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Purity:99.79%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium. |
| In vivo | laudanosine, a metabolite of atracurium and a central nervous system stimulant, might increase the minimum alveolar concentration (MAC) of halothane.?These estimates were used to determine the rates of infusion that would produce steady state plasma concentrations of laudanosine of approximately 200, 400, and 800 ng .?ml-1.?Subsequent infusion of laudanosine in eight rabbits produced mean (+/- SD) steady state plasma concentrations of laudanosine of 234 +/- 56, 457 +/- 66, and 873 +/- 105 ng .?ml-1.?The control value for MAC of halothane was 1.08 +/- 0.28%.?At the lowest steady state plasma laudanosine concentration, MAC did not significantly differ from control (MAC = 1.15 +/- 0.23%, P less than 0.1).?However, at 457 and 873 ng .?ml-1, laudanosine significantly increased the MAC of halothane by 23% and 30%, respectively.?Infusion with saline in two additional rabbits did not affect MAC. Therefore, at the plasma concentrations of laudanosine found in humans after administration of atracurium, laudanosine increased the MAC of halothane in rabbits[1]. |
| Molecular Weight | 357.44 |
| Formula | C21H27NO4 |
| Cas No. | 1699-51-0 |
| Smiles | COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC |
| Relative Density. | 1.1729 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (30.77 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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