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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $258 | In Stock | |
5 mg | $642 | In Stock | |
10 mg | $913 | In Stock | |
25 mg | $1,370 | In Stock | |
50 mg | $1,850 | In Stock | |
100 mg | $2,500 | In Stock |
Description | DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter. It effectively blocks the increase in Ca2+ influx dependent on MCU or MICU1 [1]. |
In vitro | DS16570511 effectively inhibits serum-induced mitochondrial Ca2+ (calcium) influx in HEK293A cells in a dose-dependent manner, exhibiting an IC50 value of 7 μM. Additionally, it suppresses calcium uptake in isolated mitochondria sourced from human cells, rat, and pig hearts. |
Molecular Weight | 562.44 |
Formula | C30H25Cl2N3O4 |
Cas No. | 2446154-84-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 124 mg/mL (220.47 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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