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DUB-IN-2
🥰Excellent
Catalog No. T11111Cas No. 924296-19-5
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
DUB-IN-2
🥰Excellent
Purity: 98.96%
Catalog No. T11111Cas No. 924296-19-5
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $72 | In Stock | |
| 5 mg | $175 | In Stock | |
| 10 mg | $272 | In Stock | |
| 25 mg | $546 | In Stock | |
| 50 mg | $798 | In Stock | |
| 100 mg | $1,160 | In Stock | |
| 200 mg | $1,560 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $192 | In Stock |
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Purity:98.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor. |
| Targets&IC50 | USP8:0.28 μM |
| In vitro | DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM.DUBs-IN-2 is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. |
| Molecular Weight | 275.26 |
| Formula | C15H9N5O |
| Cas No. | 924296-19-5 |
| Smiles | CCO\N=C1/c2ccccc2-c2nc(C#N)c(nc12)C#N |
| Relative Density. | 1.36±0.1 g/cm3 (20 °C, 760 mmHg) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9.06 mg/mL (32.91 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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