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E-7386

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Purity:99%

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COA HPLC HNMR

E-7386

Catalog No. T11136Cas No. 1799824-08-0

E-7386 is an oral active CBP/ -catenin modulator.

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Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$269	In Stock
10 mg	$396	In Stock
25 mg	$682	In Stock
50 mg	$969	In Stock
100 mg	$1,290	In Stock
1 mL x 10 mM (in DMSO)	$419	In Stock

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Product Introduction

Bioactivity

Description	E-7386 is an oral active CBP/ -catenin modulator.
In vivo	E-7386 is an oral active CBP/ -catenin regulator, which can induce T cells to infiltrate into the tumor in the Wnt1 tumor cogene mouse model and enhance the anti-tumor activity of anti-PD-1 monoclonal antibody.In the Wnt1 model, t-cell infiltration in the vehicle control group was limited, while t-cell infiltration in the E-7386 treatment group was obvious, and E-7386 showed significant anti-tumor activity.
Alias	E7386

Chemical Properties

Molecular Weight	725.85
Formula	C39H48FN9O4
Cas No.	1799824-08-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: 250 mg/mL (344.42 mM)

DMSO: 125 mg/mL (172.21 mM)

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3777 mL	6.8885 mL	13.7770 mL	68.8848 mL
5 mM	0.2755 mL	1.3777 mL	2.7554 mL	13.7770 mL
10 mM	0.1378 mL	0.6888 mL	1.3777 mL	6.8885 mL
20 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4442 mL
50 mM	0.0276 mL	0.1378 mL	0.2755 mL	1.3777 mL
100 mM	0.0138 mL	0.0689 mL	0.1378 mL	0.6888 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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