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EAI001
🥰Excellent
Catalog No. T61191Cas No. 892772-75-7
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
EAI001
🥰Excellent
Purity: 100%
Catalog No. T61191Cas No. 892772-75-7
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $51 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $178 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $478 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research. |
| Targets&IC50 | EGFR (L858R/T790M):24 nM |
| In vitro | EAI001 (50 μM) exhibits binding to EGFR T790M/C797S/V948R, situated deep within the EGFR near the ATP binding site and the C-helix. The inhibitory activity of EAI001 is attributed to its hydrophobic interactions with amino acids Ile759, Leu747, Leu788, Leu777, and Met766.[1] |
| Molecular Weight | 349.41 |
| Formula | C19H15N3O2S |
| Cas No. | 892772-75-7 |
| Smiles | O=C(Nc1nccs1)C(N1Cc2ccccc2C1=O)c1ccccc1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (257.58 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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