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EMI1
Catalog No. T61016Cas No. 35773-42-3
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $55 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $528 | In Stock | |
| 500 mg | $1,130 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1]. |
| In vitro | EMI1 (1 nM-100μM) significantly increase the caspase 3/7 activity and inhibits the viability and of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells. EMI1 inhibits growth of PC9 EGFR ex19del/T790M/C797S organoid with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. |
| Molecular Weight | 334.37 |
| Formula | C20H18N2O3 |
| Cas No. | 35773-42-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
| Solubility Information | DMSO: 1.8 mg/mL (5.4 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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