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EMI1
🥰Excellent
Catalog No. T61016Cas No. 35773-42-3
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1].
EMI1
🥰Excellent
Purity: 100%
Catalog No. T61016Cas No. 35773-42-3
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $119 | In Stock | |
| 50 mg | $197 | In Stock | |
| 100 mg | $317 | In Stock | |
| 200 mg | $448 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1]. |
| In vitro | EMI1 (1 nM-100μM) significantly increase the caspase 3/7 activity and inhibits the viability and of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells. EMI1 inhibits growth of PC9 EGFR ex19del/T790M/C797S organoid with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. |
| Molecular Weight | 334.37 |
| Formula | C20H18N2O3 |
| Cas No. | 35773-42-3 |
| Smiles | CCN(CC)C1=CC2=C(C=C1)C=C(C1=NC3=C(O1)C=CC=C3)C(=O)O2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 1.8 mg/mL (5.4 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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