Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 528.00 | |
500 mg | In stock | $ 1,130.00 |
Description | EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1]. |
In vitro | EMI1 (1 nM-100μM) significantly increase the caspase 3/7 activity and inhibits the viability and of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells. EMI1 inhibits growth of PC9 EGFR ex19del/T790M/C797S organoid with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. |
Molecular Weight | 334.37 |
Formula | C20H18N2O3 |
CAS No. | 35773-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.8 mg/mL (5.4 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EMI1 35773-42-3 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibitor inhibit